Macromusophagy
Identifieur interne : 000138 ( Main/Exploration ); précédent : 000137; suivant : 000139Macromusophagy
Auteurs : Wendy W-K Lee [Hong Kong] ; Daniel J. Klionsky [États-Unis]Source :
- Autophagy [ 1554-8627 ] ; 2014.
Abstract
Macroautophagy is a complex process involving dynamic membrane rearrangements in which parts of the cytoplasm are sequestered within double-membrane phagophores. Upon completion, these structures mature into autophagosomes that fuse with the yeast vacuole or mammalian lysosome, leading to degradation of the cargo and release of the resulting macromolecules back into the cytosol. How can the complexities of macroautophagy best be conveyed to an audience that is composed primarily of people who are not experts in this topic, and possibly not even scientists? The literature on learning is vast, and difficult to summarize, but there are certain themes that frequently appear. First, people learn in different ways. Thus, for example, while lectures are effective for conveying information to part of the audience, some will benefit tremendously from alternative methods of presentation. The latter can be visual (taking the form of illustrations, videos, or even physical movement), tactile or audible. Second, a line of research suggests that the engagement of more than one part of the brain (dual channels) improves learning. We decided to explore these concepts focusing on an audible format through a collaborative approach by combining a scientific explanation of macroautophagy with a musical score that was composed specifically to represent this process.
Url:
DOI: 10.4161/auto.27965
PubMed: 24675240
PubMed Central: 4013748
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Curation: 000488
- to stream Pmc, to step Checkpoint: 000116
- to stream Ncbi, to step Merge: 000704
- to stream Ncbi, to step Curation: 000704
- to stream Ncbi, to step Checkpoint: 000704
- to stream Main, to step Merge: 000138
- to stream Main, to step Curation: 000138
Le document en format XML
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<author><name sortKey="Lee, Wendy W K" sort="Lee, Wendy W K" uniqKey="Lee W" first="Wendy W-K" last="Lee">Wendy W-K Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Music Department; Chinese University of Hong Kong; Shatin, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Music Department; Chinese University of Hong Kong; Shatin</wicri:regionArea>
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<author><name sortKey="Klionsky, Daniel J" sort="Klionsky, Daniel J" uniqKey="Klionsky D" first="Daniel J" last="Klionsky">Daniel J. Klionsky</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Life Sciences Institute; University of Michigan; Ann Arbor, MI USA</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Macroautophagy is a complex process involving dynamic membrane rearrangements in which parts of the cytoplasm are sequestered within double-membrane phagophores. Upon completion, these structures mature into autophagosomes that fuse with the yeast vacuole or mammalian lysosome, leading to degradation of the cargo and release of the resulting macromolecules back into the cytosol. How can the complexities of macroautophagy best be conveyed to an audience that is composed primarily of people who are not experts in this topic, and possibly not even scientists? The literature on learning is vast, and difficult to summarize, but there are certain themes that frequently appear. First, people learn in different ways. Thus, for example, while lectures are effective for conveying information to part of the audience, some will benefit tremendously from alternative methods of presentation. The latter can be visual (taking the form of illustrations, videos, or even physical movement), tactile or audible. Second, a line of research suggests that the engagement of more than one part of the brain (dual channels) improves learning. We decided to explore these concepts focusing on an audible format through a collaborative approach by combining a scientific explanation of macroautophagy with a musical score that was composed specifically to represent this process.</p>
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